Do Ibuprofen and Tramadol Interact?

Tramadol hydrochloride (Ultram®) is a prescription opioid pain reliever. Ibuprofen (Advil®, Motrin®, Nuprin®) is a nonsteroidal anti-inflammatory drug (NSAID) that is available both over-the-counter and with a prescription, depending on the strength. There is no significant drug interaction between tramadol and ibuprofen.

Combining Tramadol and Ibuprofen

Combining these drugs can be advantageous in some situations. These two medications work differently to relieve pain, and combining them can provide additional pain relief for many people. In addition, adding ibuprofen provides an anti-inflammatory action that tramadol lacks. As a result, combining ibuprofen and tramadol may be useful in situations that involve inflammation, such as injuries.